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Single-use Bioprocess Products  Cell Culture Products  Protein Chromatography  Processing Filtration  Hydration Products 

Single-Use Bioprocess Bags & Bottles Single-Use Mixing System Aseptic Connect & Disconnect Aseptic Sampling & Filling Bioprocess Supporting Vessels Connectors and Fittings

BioHub^® 2D Single-use Storage Bag BioHub^® 3D Single-use Storage Bag NovaLinX^® Nuclease-free Single-use Consumables HemoLinX^® CFT Freezing Bag BioHub^® Single-use Storage Bottle BioHub^® Storage Bottle Tool Kit

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Cell Culture Bioreactors

Simplify Your Workflow with Advanced Disposable Bioreactors for Cell Culture

In the upstream cell culture production process of biopharmaceuticals, the disposable bioreactor is the most important production equipment. Single-use bioreactors can provide good scalability and can complete batch culture, fed-batch (fed-batch) culture, and perfusion culture. In addition, a miniature single-use bioreactor system can be used to perform high-throughput screening experiments. Single-use technology offers significant advantages over traditional fixed plant equipment, reducing the overall cost of bioprocess manufacturing.

Cell culture bioreactors have been successfully applied to mammalian cells, insect cell culture, and microbial fermentation. The types of drugs produced include antibodies, vaccines, recombinant proteins, cell therapy, and recombinant blood products. Until now, cell culture bioreactor vessels have been widely used in biopharmaceutical research and development, clinical sample production, and large-scale commercial production.

Cell Culture Bioreactor Types

CytoLinX<sup>®</sup> RW 10-200L Single-use Rocking Bioreactor

0.3-25L, a swinging reactor for cell expansion and amplification as well as process development.

CytoLinX^® RW 10-200L Single-use Rocking Bioreactor

CytoLinX<sup>®</sup> GB 1-20L Benchtop Glass Bioreactor

The CytoLinX^® GB benchtop glass bioreactors are available in 1 L, 3 L, 7 L, 15 L, and 20 L with a new design and high flexibility, allowing the use of existing brands of electrodes, tubes, gas distributors and stirring paddle.

CytoLinX^® GB 1-20L Benchtop Glass Bioreactor

CytoLinX<sup>®</sup> BR 10-2000L Single-use Bioreactor

10-2000L, a disposable bioreactor suitable for mass production, its automatic control logic complies with ISA 88 control standard.

CytoLinX^® BR 10-2000L Single-use Bioreactor

Reasons to Choose BioLink Single-Use Bioreactors

1. Designed for Large-Scale Commercial Production

BioLink's single-use bioreactor for cell culture is highly suitable for large-scale and commercial operations. Users can connect and control multiple reaction tanks through a single integrated control cabinet, effectively reducing both equipment and operation costs. This disposable bioreactor for cell culture design significantly improves scalability and plant efficiency, supporting seamless expansion as production needs grow. With high compatibility and modular design, several single-use bioreactor for cell culture units can operate simultaneously under unified supervision.

2. Advanced Control System and Compliance

The CytoLinX® BR series bioreactor adopts the stable PCS 7 system, fully compliant with the ISA 88 automation control standard. The disposable bioreactor for cell culture can achieve plant-wide centralized control, ensuring consistent and reliable performance across the entire manufacturing line. Furthermore, the software design meets the requirements of 21 CFR Part 11, providing secure data management for regulated environments. This single-use bioreactor for cell culture also allows flexible configuration and partial customization according to user applications and process preferences.

3. Reliable Performance and Rigorous Quality Testing

Each CytoLinX® BR series single use perfusion bioreactor is rigorously tested at the factory to guarantee reliability and stability before delivery. The single-use bioreactor for cell culture utilizes high-quality components to ensure long-term operational safety. As a leading manufacturer of bioprocessing products, BioLink provides customers with complete FAT, SAT, IQOQ documents and services. This ensures the disposable bioreactor for cell culture is fully validated upon installation and ready for immediate use.

4. Optimized Consumables for Process Flexibility

The corresponding bioreactor consumables feature different types of spargers — large bubbles, medium bubbles, and microbubbles — enabling flexible adjustment for various cell culture processes. Whether in perfusion, fed-batch, or batch mode, the disposable bioreactor for cell culture can precisely meet oxygen transfer and mixing requirements. This adaptability allows process engineers to optimize culture conditions for different cell lines efficiently.

5. Comprehensive Technical and Engineering Support

Our engineering team has extensive experience in single-use bioreactors for cell culture and can provide rapid technical support and troubleshooting. BioLink’s global after-sales network ensures every disposable bioreactor for cell culture operates at peak performance, guaranteeing users a stable and efficient production experience.

FAQs of Single-Use Bioreactors

What is the difference between a conventional bioreactor and a single-use bioreactor?

Compared with traditional reactors, single-use bioreactors have many advantages. Single-use bioreactors can be quickly introduced into laboratories and manufacturing facilities at pilot scale because installation, qualification, and personnel training requirements are lower. Additionally, cleaned and pre-sterilized single-use consumables provide greater reliability. Single-use cell culture reactors can also increase plant capacity and flexibility by reducing turnaround times, especially reducing setup times in the event of contamination. Since single-use bioreactors require significantly less piping, valves, and instrumentation, they also have a smaller footprint. Design changes can also be implemented faster using disposables, allowing for continuous improvement and integration of new technologies, such as online monitoring systems. Collectively, these advantages can significantly reduce the overall cost and resource requirements of bioprocessing, which is a key consideration for biomanufacturers.

FAQ

Do single-use bioreactors need to be used with disposable consumables?

Yes. The disposable cell bioreactor must be used together with the supporting specifications of disposable consumables. CytoLinX^® BR disposable bioreactor bag uses RENOLIT 9101 film, and the liquid contact layer is made of ULDPE, which has good biocompatibility and chemical compatibility. In addition, this type of material also ensures that the content of extractables is kept low. The ventilation base of the CytoLinX^® BR disposable bioreactor bag contains 6 ventilation dial components, and the ventilation holes are available in 50um, 300um, 500um, 1mm and other specifications. The uniformity of the pore size is stable, and the ventilation combination can be freely matched, which is suitable for different processes. In addition, the 2000L agitator is made of engineering plastic Peek material, which has stronger hardness, and the N40E design has low shear force and short mixing time.

FAQ

What are the advantages of BioLink's single-use bioreactor system?

BioLink has different cell culture bioreactor types, each suitable for different scenarios. CytoLinX^® WB disposable wave bioreactor adopts functional block design, and the required modules can be freely selected to realize pH&DO function, perfusion function, ventilation function, etc. A single control cabinet of CytoLinX^® BR single use stirred tank bioreactor can control multiple reaction tanks through plugging and unplugging, which can greatly reduce the cost. It adopts stable PCS 7 system, complies with ISA 88 control standard, and can realize whole plant control. In the jacket insulation performance test, when the Bio-Link bioreactor tank was powered off for 15 hours, the water inside the tank only dropped by less than 5 degrees. The insulation performance of the jacket of this product also ensures that the reactor can achieve high temperature control accuracy.

FAQ

Link With Us Now!

Want to know more about BioLink bioprocessing products? Feel free to contact BioLink now!

info@biolink.com

Phone

0086-400-058-9000

ADDRESS

BioHub<sup>®</sup> Automated Bioprocess Analyzer

09 Jan 2026

Cell Culture Bioreactors

Cell Culture Bioreactor Types

Reasons to Choose BioLink Single-Use Bioreactors

FAQs of Single-Use Bioreactors

Q What is the difference between a conventional bioreactor and a single-use bioreactor?

Q Do single-use bioreactors need to be used with disposable consumables?

Q What are the advantages of BioLink's single-use bioreactor system?

What is the difference between a conventional bioreactor and a single-use bioreactor?

Do single-use bioreactors need to be used with disposable consumables?

What are the advantages of BioLink's single-use bioreactor system?