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absorption column chromatography
absorption column chromatography
multi column chromatography
wet column chromatography

Chrom-LinX® Auto Automated Chromatography Column

The Chrom-LinX® Auto Automated Chromatography Columns are designed for downstream purification of biopharmaceuticals. They are operated by automated control software (with the BioLink Packing-LinX® column packing workstation), to minimize the cumbersome manual operation of conventional columns. Column packing with the BioLink Slurry-LinX® series slurry tank allows the entire process to remain in a closed environment for most of the time, minimizing the risk of exposure and contamination of the chromatography resin and homogenizing solution.


Chrom-LinX® Auto Automated Chromatography Columns have been carefully designed and proven to provide excellent performance with most of the different types of resin. They are compatible with the ChromaX® chromatography resins from BioLink, and perform very well when filled with Chromstar FF and MaXtar series resins of high rigidity and flow rate. The software in the workstation presets the packing method of relevant resins, which can simplify the packing process and improve the production efficiency.


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Overview Features Specifications Material Workstation Ordering Information Contact us

Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.


Overview of Chrom-LinX® Auto Automated Chromatography Column

Chrom-LinX® Auto Automated Chromatography Column works in a low-pressure and axial compression mode as a standardized equipment with ID of 450, 600, 800, 1000, 1200 mm and column tube height of 700 mm (1000 mm customizable), making itself suitable for the manufacturing of various types and scales of bioproducts.


The exhaust structure of the columns has been carefully designed and tested to allow for easy exhaust and cleanliness of the column head, reducing cleaning and maintenance steps. The design of the column head distribution plate ensures uniform distribution of liquid flow. The packing process is controlled by software in the column packing workstation, which enables intelligent loading and unloading, as well as automated packing, dismantling and maintenance operations through programming, ensuring the stability and reproducibility of packing. A pre-homogenized resin is pumped into the column through the inlet at the column bottom. The column head is driven upwards by a servo motor, and after pumping in a sufficient amount of homogenate, the column head moves downwards to pack the resin. The speed of the column head can be set by software, and the accuracy of the movement distance can reach 1mm. The height of the column bed can be precisely controlled so that the resin forms a uniform and stable bed structure within the column.


Features of Chrom-LinX® Auto Automated Chromatography Column

  • Column tube is acrylic structure, clear vision, column bed position visible.

  • Sanitary design, in line with GMP requirements.

  • Material safety, in line with the regulatory requirements.

  • Scientific design, no clean dead corner.

  • Can be used for a variety of packing.

  • Specifications of inner diameter: 300, 450, 600, 800, 1000, 1200 mm.

  • Height range: 550 and 570 mm.

  • Screen aperture: 10μm and 20μm are optional.


Specifications of Chrom-LinX® Auto Automated Chromatography Column

Specification

Chrom-LinX

450/700

Chrom-LinX

600/700

Chrom-LinX

800/700

Chrom-LinX

1000/700

Column inner diameter (mm)

450

600

800

1000

Column bed height (cm)

5-30

5-30

5-30

5-30

Column head lift height (cm)

0-68

0-68

0-68

0-62

Minimum operating height (mm)

1690

1750

1790

2000

Maximum operating height (mm)

2365

2410

2470

2690

Maximum maintenance height (mm)

2480

2540

2610

2850

Maximum operating pressure

0.3 MPa (3 bar or 43.5 psi)

Empty column weight (kg)

500

1000

1700

2630

Footprint (mm×mm)

1160×610

1350×800

1510×1000

1740×1220

Operating temperature

2-40℃

Pore size of sieve plate

10μm, 20μm


Material of Chrom-LinX® Auto Automated Chromatography Column

Chrom-LinX® Auto Automated Chromatography Columns are made of materials suitable for biopharmaceutical production. The structural materials conform to ASME biological processing equipment standards, and the wetted polymer materials and elastic materials meet the requirements of USP<88> in vivo biological reactivity test and FDA 21 CFR Part 177. All materials contain no ingredients of animal origin and comply with the regulations in EMA/410/01 2nd edition. The parts used are traceable back to the product batch. Wetted parts can withstand most chemical reagents commonly used in chromatography, such as buffers or organic reagents for adsorption, elution, washing and preservation, as well as disinfectant solutions.


Parts

Material description

Column tube

Acrylic

O-ring

EPDM+UPE

Distribution plate

PP

Column head adapter

316L stainless steel

Column head

2205 stainless steel

Net ring

316L/904L stainless steel

Tubing/Fittings

316L stainless steel

Medium valve body

PP

Support

304 stainless steel

Caster

Nylon + polyurethane


Packing-LinX® Column Packing Workstation

The Packing-LinX® Column Loading Workstation enables 21 CFR Part 11 compliant packing operations. Chromatography columns are operated via the touch screen of the workstation. The workstation supports functions including venting, filling, disassembly, and maintenance besides corresponding programs, which can be selected and set by the operator as needed. During the packing process, the equipment will stop automatically when the set compression factor or height is reached, or the operator can stop it manually at any time.


Packing-LinX Column Packing Workstation


Ordering Information of Chrom-LinX® Auto Automated Chromatography Column

Chromatography column

Pore size of sieve plate

Product code

Chrom-LinX Auto 450/700


2345-1221

Chrom-LinX Auto 600/700


2360-1221

Chrom-LinX Auto 800/700

20μm

2380-1221

Chrom-LinX Auto 1000/700


2310-1221

Chrom-LinX Auto 1200/700


2312-1221

Chrom-LinX Auto 450/700S


2345-1211

Chrom-LinX Auto 600/700S


2360-1211

Chrom-LinX Auto 800/700S

10μm

2380-1211

Chrom-LinX Auto 1000/700S


2310-1211

Chrom-LinX Auto 1200/700S


2312-1211


Accessories

SpecificationProduct code

Braided silicone tubing

3/8 inch, ID 9.5mm, TC25 chuck, 2m in length

2611-1121

Braided silicone tubing

3/4 inch, ID 19mm, TC25 chuck, 4m in length

2611-1221

Braided silicone tubing

1 inch, ID 25.4mm, TC50 chuck, 4m in length

2611-1321

Braided silicone tubing

3/8 inch, 316L material, four-way, one-pass, TC25

2611-1341

Braided silicone tubing

1.5 inch, ID 38.1mm, TC50 chuck, 4m in length

2611-1442

Cross valve

1/2 inch, 316L material, four-way, one-pass, TC25

2621-1121

Cross valve

1 inch, 316L material, four-way, one-pass, TC50

2621-1152

Diaphragm valve

DN15, chuck end, ID 9.4mm, 316L material, TC25

2622-2011

Diaphragm valve

DN20, chuck end, ID 15.75mm, 316L material, TC25

2622-2031

Diaphragm valve

DN25, chuck end, ID 22.1mm, 316L material, TC50

2622-2042

Diaphragm valve

DN40, chuck end, ID 22.1mm, 316L material, TC50

2622-2052

Chuck

TC25, 304 stainless steel

2631-1010

Chuck

TC50, 304 stainless steel

2631-1020

Gasket

3/8 inch, TC25, EPDM

2632-3110

Gasket

1/2 inch, TC25, EPDM

2632-3210

Gasket

3/4 inch, TC25, EPDM

2632-3310

Gasket

1 inch, TC50, EPDM

2632-3420

Gasket

1.5 inch, TC50, EPDM

2632-3520

Upper column head 

o-ring

EPDM(Chrom-LinX Auto 450)

2345-4110

Upper column head 

o-ring

EPDM(Chrom-LinX Auto 1000)

2310-4110

Upper column head scraper

UPE(Chrom-LinX Auto 450)

2345-4220

Upper column head scraper

UPE(Chrom-LinX Auto 1000)

2310-4220

Bottom column head 

o-ring

EPDM(Chrom-LinX Auto 450)

2345-4310

Bottom column head 

o-ring

EPDM(Chrom-LinX Auto 1000)

2310-4310

Upper sieve plate

316L stainless steel, 10μm

2345-2131

Upper sieve plate

316L stainless steel, 20μm

2345-2132

Upper sieve plate

316L stainless steel, 10μm

2310-2131

Upper sieve plate

316L stainless steel, 20μm

2310-2132

Bottom sieve plate

316L stainless steel, 10μm

2345-2231

Bottom sieve plate

316L stainless steel, 20μm

2345-2232

Bottom sieve plate

316L stainless steel, 10μm

2310-2231

Bottom sieve plate

316L stainless steel, 20μm

2310-2232


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