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chrom linx manual compression chromatography column 1
chrom linx manual compression chromatography column 1
chrom linx manual compression chromatography column

Chrom-LinX® Manual Compression Chromatography Column

Chrom-LinX® manual chromatography columns are the ideal choice for purification applications. Specifically designed to meet the needs for the chromatography process development in biopharmaceuticals, these columns can be packed with various commonly used media available in the market, including "soft gels"1 like dextran-based agaros, as well as "hard gels" like poly (styrene divinylbenzene) (PS-DVB)2 and hydroxyapatite3. They provide an ideal column platform with high versatility, adaptability and stability. Utilizing the widely adopted rotation compression sealing method in the industry, the simplified design of Chrom-LinX® columns significantly enhances the user experience, and improve the efficiency and success of media packing. 


The Chrom-LinX® series columns are designed to optimize the user experience by offering a comprehensive range of optional accessories and spare parts including tubing, valves, consumables, etc. Such a ecosystem empowers users to confidently tackle chromatography processes without any apprehensions about purification challenges.




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Features Material Specifications Contact us

Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.


Features of Chrom-LinX® Manual Compression Chromatography Column

  • The SCHOTT borosilicate glass column tubing, with precise column tubing inner diameter and smooth coaxial circumference, ensures meticulous and efficient separation and purification.

  • The upper and lower sieves of the column are made of USP <88> Class material, and based on the customized plastic sealing process of BioLink. The column is endowed with low flow pressure difference, high liquid dispersion ability, and excellent distribution performance.

  • Sealing components are made of EPDM material in accordance with USP <88> Class, providing excellent sealing performance with a minimal dead cavity volume.

  • All parts in contact with the liquid are made of pharmaceutical-grade high-quality stainless steel, offering excellent rigidity and corrosion resistance.

  • The tubing connection is based on sanitary Tri-Clamp quick fittings, and the sanitary design of the whole flow path ensures the cleanliness of the column.

  • Optimized screw lifting and O-ring sealing handles for operating sensations make the operation effortless.

  • The bottom is designed with a side outlet interface for easy connection to valve tubing connector and other components. The micro-slope design ensures efficient liquid drainage, easy cleaning, and no dead corners.

  • Adaptive column packing reservoirs with a variety of specifications are available to facilitate packing of higher column beds.


Material of Chrom-LinX® Manual Compression Chromatography Column

Parts

Material

Column tubingSCHOTT borosilicate glass

Metal parts in contact with fluids

ASTM 316L/2205 stainless steel

Sealing components

EPDM

O-ring knobs

PEEK

Distribution plates*

PP (Polypropylene)

Support screen**

PP (Polypropylene)

Sieve (10μm/23μm)

10μm sieve made of PA (nylon)

23μm sieve made of PP (polypropylene)

Support

304 stainless steel

Caster

PU (Polyurethane)

*Chrom-LinX 300/X chromatography columns are equipped with distribution plate, with no support screen.

**Chrom-LinX 100/X, 140/X, 200/X chromatography columns are equipped with support screens, with no distribution plate.



Specifications of Chrom-LinX® Manual Compression Chromatography Column

Product Code and Specification Table

Product codeProduct nameColumn tube material

Inner 

diameter

of

column 

tubing

(mm)

Height

of 

column 

tubing

(mm)

Height

of 

column 

bed

(mm)

Volume 

of 

column 

bed

(L)		Maximum 
operating 
pressure
(bar)
2210-1131Chrom-LinX 100/500Glass10050050-3500.4-2.85
2210-1132Chrom-LinX 100/750Glass100750200-5801.6-4.55
2210-1133Chrom-LinX 100/950Glass100950400-7503.9-5.85
2214-1131Chrom-LinX 140/500Glass14050050-3500.8-5.35
2214-1132Chrom-LinX 140/750Glass140750200-5803.0-8.95
2214-1133Chrom-LinX 140/950Glass140950400-7507.7-11.55
2220-1131Chrom-LinX 200/500Glass20050050-3501.6-114.4
2220-1132Chrom-LinX 200/750Glass200750200-5806.28-18.24.4
2220-1133Chrom-LinX 200/950Glass200950400-75015.7-224.4
2230-1131Chrom-LinX 300/500Glass29650050-3503.5-24.74.4
2230-1132Chrom-LinX 300/750Glass296750200-58014.2-40.94.4
2230-1133Chrom-LinX 300/950Glass296950400-75028.3-52.94.4


Common Accessories

Product codeNameSpecification
2611-1771Braided silicone tubing1/4", ID 4.76mm, TC25 chuck, 1.5m in length
2611-1171Braided silicone tubing3/8", ID 7.9mm, TC25 chuck, 1.5m in length
2611-1711Braided silicone tubing1/4", ID 4.76mm, TC25 chuck, 1m in length
2611-1721Braided silicone tubing1/4", ID 4.76mm, TC25 chuck, 2m in length
2611-1731Braided silicone tubing1/4", ID 4.76mm, TC25 chuck, 3m in length
2611-1741Braided silicone tubing1/4", ID 4.76mm, TC25 chuck, 4m in length
2611-1751Braided silicone tubing1/4", ID 4.76mm, TC25 chuck, 0.2m in length
2611-1761Braided silicone tubing1/4", ID 4.76mm, TC25 chuck, 0.3m in length
2621-1111Cross valve1/4", 316L material, four-way, one-pass, TC25
2621-1211Cross valve1/4", 316L material, four-way, two-pass, TC25
2621-1121Cross valve3/8", 316L material, four-way, one-pass, TC25
2621-1221Cross valve3/8", 316L material, four-way, two-pass, TC25
2622-2011Diaphragm valve

1/4", two-way diaphragm valve, 

316L stainless steel,

EPDM diaphragm

2622-2021Diaphragm valve

3/8", two-way diaphragm valve, 

316L stainless steel,

EPDM diaphragm

2641-3111Bottom elbow component

Suitable for 100mm column, 1/4", TC25,

316L stainless steel

2641-4111Bottom elbow component

Suitable for 140mm column, 1/4", TC25,

316L stainless steel

2641-6112Bottom elbow component

Suitable for 200mm column, 3/8", TC25,

316L stainless steel

2641-7112Bottom elbow component

Suitable for 300mm column, 3/8", TC25,

316L stainless steel

2210-6111Column packing reservoir100/500
2214-6111Column packing reservoir140/500
2220-6111Column packing reservoir200/500
2230-6111Column packing reservoir300/500
2632-3610Gasket1/4", TC25, EPDM
2632-4110Gasket3/8", TC25, PTFE
2631-1010ChuckTC25, 304 stainless steel
2633-2010Blind plateTC25, 316L stainless steel
2210-4110Upper column head o-ringEPDM(Chrom-LinX 100)
2214-4110Upper column head o-ringEPDM(Chrom-LinX 140)
2220-4110Upper column head o-ringEPDM(Chrom-LinX 200)
2230-4110Upper column head o-ringEPDM(Chrom-LinX 300)
2210-4210

Bottom column head

o-ring

EPDM(Chrom-LinX 100)
2214-4210

Bottom column head

o-ring

EPDM(Chrom-LinX 140)
2220-4210

Bottom column head

o-ring

EPDM(Chrom-LinX 200)
2230-4210

Bottom column head

o-ring

EPDM(Chrom-LinX 300)
2210-2112Upper net ringPP, 23μm
2210-2121Upper net ringPA, 10μm
2214-2112Upper net ringPP, 23μm
2220-2112Upper net ringPP, 23μm
2220-2121Upper net ringPA, 10μm
2230-2112Upper net ringPP, 23μm
2230-2121Upper net ringPA, 10μm
2210-2212Bottom net ringPP, 23μm
2210-2221Bottom net ringPA, 10μm
2214-2212Bottom net ringPP, 23μm
2214-2221Bottom net ringPA, 10μm
2220-2212Bottom net ringPP, 23μm
2220-2221Bottom net ringPA, 10μm
2230-2212Bottom net ringPP, 23μm
2230-2221Bottom net ringPA, 10μm
2651-1111Stirring rodsPP, chassis diameter 80mm, rod 1m in length
2651-1121Stirring rodsPP, chassis diameter 140mm, rod 1m in length
2651-1131Stirring rodsPP, chassis diameter 200mm, rod 1m in length





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