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CytoLinX® BRTF Single-use Top-driven Bioreactor Bag

The core of the CytoLinX® BRTF 50 L microbial fermentation system is the single-use microbial bioreactor bag designed to meet the stringent requirements of microbial fermentation. It is used for cultivating various organisms, including E-coli, pseudomonas, and yeast. The single-use microbial bioreactor bag is based on the proven design and materials of the CytoLinX® BRTF Single-Use Bioreactor Bag for mammalian cell culture.

  • RENOLIT 9101 multilayer co-extruded film, ULDPE liquid contact layer, offering excellent biocompatibility and chemical compatibility while ensuring low levels of extractable content.

  • The dual impeller design enables vigorous mixing of the culture, and the bottom magnetic coupling eliminates external shafts, minimizing the risk of leakage.

  • All single-use microbial bioreactor bags are equipped with pressure sensors to maintain bag integrity during demanding fermentation processes.

  • The vent filter is equipped with a condensation bag at the front end to integrate condensation, returning water vapor from the gas back into the bag, ensuring the ventfilter remains unclogged.

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Features of CytoLinX® BRTF Single-use Top-driven Bioreactor Bag

CytoLinX® BRTF Single-use Top-driven Bioreactor Bag is designed to match single-use top mechanical coupling bioreactor used in biopharmaceuticals. The product can be used for scientific research, process development and commercial production of CHO, Vero, and MDCK cells, etc.

  • RENOLIT 9101 multilayer co-extruded film, ULDPE fluid contact layer, offering excellent biocompatibility and chemical compatibility while ensuring low levels of extractable content

  • The porous-frit microsparge column is designed from ultra-high molecular weight polyethylene (UHMW- PE), with pore sizes ranging from 20-40 μm. The generated bubbles possess a high surface area ratio and good oxygen transfer. UHMW-PE exhibits outstanding impact resistance, wear resistance, chemical corrosion resistance, physiological inertness, adaptability, and hydrophobicity

  • The macro-perforated microporous membrane is a dispersed aeration disc based on film. Laser-drilled to maintain uniform pore size, various specifications such as 0.178mm, 0.233mm, 0.368mm, 0.445mm, 0.582mm are available, tailored with specific apertures and quantities for each bag specification

  • Equipped with imported filters to ensure bag integrity

  • All pipelines can be flexibly customized

  • Fully validated, complete validation reports can be provided


Specifications of CytoLinX® BRTF Single-use Top-driven Bioreactor Bag

Standard Configuration of CytoLinX® BRTF Single-use Top-driven Bioreactor Bags

Volume

Version

Cat. No.

Configuration

brtf single use top driven bioreactor bags

Micro +

Macro

sparge 5:1


BRTF-

0050-C201

  • a (top-driven mixing parts): 3-blade impeller, diameter: 111.1 mm, angle: 45°

  • b (headspace gas): pressure sensor, CF2VTV0.2-33B1 (Meissner), 20 cm1/2" x 3/4" C-Flex + 16 cm 1/4" x 7/16"C-Flex, 6 # quick plug for gas tubing

  • c (intlet / feeding port): 150 cm 1/4" x 7/16" C-Flex, 30 cm 1/8" x 1/4" C-Flex plug

  • k (intlet / feeding port): 150 cm 3/8" x 5/8" C-Flex, Y connector

  • tubing 1: 40 cm 3/8" x 5/8" C-Flex, plug;

  • tubing 2: 10 cm 3/8" x 5/8" C-Flex, 30 cm 1/4" x 7/16" C-Flex, plug

  • l (intlet): 180 cm 3/8" x 5/8" C-Flex, plug

  • n (feeding port): 15 cm 1/4" x 7/16" C-Flex, 150 cm 1/8" x 1/4" C-Flex, plug

  • m (vent filter): CS2VTV0.2-002 (Meissner), Y connector

  • tubing 1: 25 cm 1/2" x 3/4" C-Flex; tubing 2: 15 cm 1/2" x 3/4" C-Flex, AseptiQuik® G sterile connector, 1/2"HB

  • d, e, f, g (sensor): AseptiQuik® G sterile connector, 1/2"HB

  • h (sampling port): 30 cm 1/8" x 1/4" C-Flex, needless sampling 50 cm 1/8" x 1/4" C-Flex, plug

  • i (sensor): thermowell, ID3.5 mm

  • j (harvest port): 100 cm 1/2" x 3/4" C-Flex, 30 cm 3/8" x 5/8" C-Flex, plug

  • o, p (bottom gas): CF2VTV0.2-33B1 (Meissner), 15 cm 1/4" x 7/16"C-Flex, one-way valve, 150 cm 1/4" x 7/16" C-Flex, 6 # quick plug for tubing

Micro +

Marco

sparge 2:1


BRTF-

0050-C202



Volume

Version

Cat. No.

Configuration

CytoLinX® BRCF Single-Use Top-Driven Bioreactor Bag

Micro + Macro

sparge 5:1

BRTF-

0250-C201

  • a (top-driven mixing parts): 3-blade impeller, diameter: 251 mm, angle: 45°

  • i (headspace gas): pressure sensor, CS2VTV0.2-002 (Meissner),

  • 20 cm1/2" x 3/4" C-Flex + 16 cm 1/4" x 7/16"C-Flex, 6# quick plug for gas tubing

  • m (feeding port): 15 cm 1/4" x 7/16" C-Flex, 180 cm 1/8" x 1/4" C-Flex, plug

  • k, l (intlet/feeding port): 150 cm 3/8" x 5/8" C-Flex, Y connector,

  • tubing 1: 30 cm 3/8" x 5/8" C-Flex, plug;

  • tubing 2: 20 cm 3/8" x 5/8" C-Flex, 40 cm 1/8" x 1/4" C-Flex, plug

  • n (intlet/feeding port): 150 cm 1/4" x 7/16" C-Flex, 50 cm 1/8" x 1/4" C-Flex, plug

  • j (vent filter): CL2VTV0.2-002 (Meissner), Y connector,

  • tubing 1: 30 cm 1/2" x 3/4" C-Flex;

  • tubing 2: 20 cm 1/2" x 3/4" C-Flex, AseptiQuik® G sterile connector, 1/2"HB

  • b, c, d, e (sensor): AseptiQuik® G sterile connector, 1/2"HB

  • g (sampling port): 30 cm 1/8" x 1/4" C-Flex, needless sampling;

  • 50 cm 1/8" x 1/4" C-Flex, plug

  • f (sensor): thermowell, ID3.5 mm

  • h (harvest port): 150 cm 1/2" x 3/4" C-Flex, plug

  • o, p (bottom gas): CF2VTV0.2-33B1 (Meissner), 15 cm 1/4" x 7/16"C-Flex, one-way valve, 150 cm 1/4" x 7/16" C-Flex, 6# quick plug for gas tubing

Micro + Marco

sparge 2:1

BRTF-

0250-C202

CytoLinX® BRCF Single-Use Top-Driven Bioreactor Bag

Micro + Macro

sparge 5:1

BRTF-

0500-C201

  • a (top-driven mixing parts): 3-blade impeller, diameter: 251 mm, angle: 45°

  • k (headspace gas): pressure sensor, CS2VTV0.2-002 (Meissner),

  • 25 cm 1/2" x 3/4" C-Flex + 16 cm 1/4" x 7/16"C-Flex, 6# quick plug for gas tubing

  • l (feeding port): 15 cm 1/4" x 7/16" C-Flex, 230 cm 1/8" x 1/4" C-Flex, plug

  • m (intlet/feeding port): 250 cm 1/4" x 7/16" C-Flex, plug,

  • n, o (intlet/feeding port): 180 cm 3/8" x 5/8" C-Flex, connector

  • tubing 1: 30 cm 3/8" x 5/8" C-Flex, plug;

  • tubing 2: 30 cm 3/8" x 5/8" C-Flex, 30 cm 1/8" x 1/4" C-Flex, plug

  • p (intlet/feeding port): 250 cm 3/8" x 5/8" C-Flex, plug

  • j (vent filter): CUVTV0.2-1N002 (Meissner), connector, tubing 1: 30 cm 3/4" x 1" C-Flex; tubing 2: 20 cm 3/4" x 1" C-Flex, AseptiQuik® G sterile connector, 1/2"HB

  • b, c, d, e, f (sensor): AseptiQuik® G sterile connector, 1/2"HB

  • g (sampling port): 30 cm 1/8" x 1/4" C-Flex, needless sampling; 80 cm 1/8" x 1/4" C-Flex, plug

  • h (sensor): thermowell, ID3.5 mm

  • i (harvest port): 150 cm 1/2" x 3/4" C-Flex, plug

  • q, r (bottom gas): CS2VTV0.2-002 (Meissner), 16 cm 1/4" x 7/16"C-Flex, one-way valve, 185 cm 1/4" x 7/16" C-Flex, 6# quick plug for gas tubing


Volume

Version

Cat. No.

Configuration

CytoLinX® BRCF Single-Use Top-Driven Bioreactor Bag

Micro + Macro

sparge 5:1

BRTF-

1000-C201

  • a (top-driven mixing parts): 3-blade impeller, diameter: 321 mm, angle: 45°

  • k (headspace gas): pressure sensor, CS2VTV0.2-002 (Meissner), 50 cm1/2" x 3/4" C-Flex + 20 cm 1/4" x 7/16"C-Flex, 6# quick plug for gas tubing

  • l (feeding port): 15 cm 1/4" x 7/16" C-Flex, 250 cm 1/8" x 1/4" C-Flex, plug

  • m (intlet/feeding port): 250 cm 1/4" x 7/16" C-Flex, 30 cm 1/8" x 1/4" C-Flex, plug

  • n, o (intlet/feeding port): 250 cm 3/8" x 5/8" C-Flex, connector, tubing 1: 30 cm 3/8" x 5/8" C-Flex, plug; tubing 2: 20 cm 3/8" x 5/8" C-Flex, 35 cm 1/8" x 1/4" C-Flex, plug

  • j (vent filter): CUVTV0.2-1N002 (Meissner)×2, connector, tubing 1: 25 cm 3/4" x 1" C-Flex; tubing 2: 25 cm 3/4" x 1" C-Flex

  • b, c, d, e, f (sensor): AseptiQuik® G sterile connector, 1/2"HB

  • g (sampling port): 30 cm 1/8" x 1/4" C-Flex, needless sampling; 80 cm 1/8" x 1/4" C-Flex, plug

  • h (sensor): thermowell, ID3.5 mm

  • i (harvest port): 160 cm 1/2" x 3/4" C-Flex, 30 cm 3/8" x 5/8" C-Flex,  connector

  • tubing 1: 30 cm 3/8" x 5/8" C-Flex, plug;

  • tubing 2: 20 cm 3/8" x 5/8" C-Flex, 35 cm 1/8" x 1/4" C-Flex, plug • p, q (bottom gas): CS2VTV0.2-002 (Meissner), 16 cm

  • 1/4" x 7/16"C-Flex, one-way valve, 185 cm 1/4" x 7/16" C-Flex, 6# quick plug for gas tubing

CytoLinX® BRCF Single-Use Top-Driven Bioreactor Bag

spacer.gif

Micro + Macro

sparge 5:1

BRTF-

2000-C201

  • a (top-driven mixing parts): 3-blade impeller, diameter: 397 mm, angle: 45°

  • c (headspace gas): pressure sensor, CS2VTV0.2-002 (Meissner), 50 cm 1/2" x 3/4" C-Flex + 30 cm 1/4" x 7/16"C-Flex, 6# quick plug for gas tubing

  • d, g (ifeeding port): 50 cm 1/4" x 7/16" C-Flex, 220 cm 1/8" x 1/4" C-Flex, plug

  • e (intlet/feeding port): 220 cm 1/2" x 3/4" C-Flex, 50 cm 3/8" x 5/8" C-Flex, plug

  • f (intlet/feeding port): 220 cm 1/4" x 7/16" C-Flex, 50 cm 1/8" x 1/4" C-Flex, plug

  • h (intlet): 15 cm 1" x 1 - 3/8" C-Flex, connector (internal extended tube)，

  • tubing 1: 15 cm 3/4" x 1" C-Flex, 250 cm 1/2" x 3/4" C-Flex, plug;

  • tubing 2: 15 cm 3/4" x 1" C-Flex, 250 cm 1/2" x 3/4" C-Flex, plug;

  • b (vent filter): CUVTV0.2-1N002 (Meissner)×2, Y connector,

  • tubing 1: 30 cm 3/4" x 1" C-Flex;

  • tubing 2: 30 cm 3/4" x 1" C-Flex;

  • i, j, k, l, m (sensor): AseptiQuik® G sterile connector, 1/2"HB

  • n (sampling port): 30 cm 1/8" x 1/4" C-Flex, needless sampling; 80 cm 1/8" x 1/4" C-Flex, plug

  • o (sensor): thermowell, ID3.5 mm

  • p (harvest port): 200 cm 3/4" x 1" C-Flex, TC 50

  • q, r, s, t (bottom gas): CS2VTV0.2-002 (Meissner), 8 cm1/4" x7/16" C-Flex, one-way valve, 200 cm 1/4" x 7/16" C-Flex, 6# quick plug for gas tubing


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