CytoLinX^® BR 50-2000L Single-use Bioreactor

Name: CytoLinX ® BR 50-2000L Single-use Bioreactor
Brand: Bio-Link
Price: 100 USD

CytoLinX^® BR 50-2000L Single-use Bioreactor is developed based on DCS architecture, and its underlying logic is built by Siemens PCS 7, so as to cover the automatic control requirements from R&D to production, from a single unit to the whole upstream plant, and its automatic control logic conforms to ISA 88 control standards. The disposable bioreactor for cell culture can cover 50, 200, 500, 1000, 2000 L scale, its software design in accordance with GMP and 21 CFR Part 11 requirements. At the same time, in order to facilitate the use of users, CytoLinX^® BR 50-2000L Single-use Bioreactor is minimal, all functions at a glance, and can greatly meet the needs of customers. The automatic control system can meet the functions of real-time data acquisition and recording, PID automatic control, online monitoring, multi-parameter cascade control, and has stable pH, DO, temperature control performance.

For more efficient mixing, BioLink has introduced a new bottom dial design that can maintain a high linear KLa. And provide microbubble, medium bubble, large bubble and a variety of combinations of consumable solutions, to meet the needs of a variety of cells tricky culture.

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More About CytoLinX^® BR 50-2000L Single-use Bioreactor

The supporting single-use consumables can be selected according to the needs of customers, such as micro-bubble, medium-bubble, big-bubble and other ventilation combinations. The perfusion bioreactor has a stable linear KLa, and the cultivation effect is comparable to most reactors on the market.

Functions of CytoLinX^® BR 50-2000L Single-use Bioreactor

CytoLinX^® BR 50-2000L Single-use Bioreactor comes standard with working volumes of 50 L, 200 L, 500 L, 1000 L, and 2000 L. Including a vessel, a controller and a temperature control unit (TCU), it is used for culturing mammalian cells, insect cells, and other low shear-rate needed cells.

2000l Single Use Bioreactor

Figure 1 CytoLinX^® BR single-use bioreactor (50–2000 L)

CytoLinX^® BR Controller — The Controller of Single-use Bioreactor

CytoLinX^® BR controller consists of control hardware and underlying hardware modules. CytoLinX^® BR's controller is built with SIEMENS PCS 7 which meets the automation requirements from research to production, as well as from single system to enterprise-wide solution. The software fits lSA 88 control standard and 21 CFR Part 11.

Hardware control units are all built with international famous brands to ensure robust and reliable performance. Also, a choice of PAT tools can be configured flexibly to meet different customer needs and applications.

One CytoLinX^® BR controller can control different types of BioLink single-use Bioreactors vessels at the same time. We can also use CytoLinX^® BR controller as an integrated control center to realize upstream centralized control by controlling several single-use Bioreactors vessels simultaneously.

Single Use Stirred Tank Bioreactor

Figure 2 Main operating interface of CytoLinX^® BR Controller

CytoLinX^® BR Vessel — The Vessel of Single-use Bioreactor

CytoLinX^® BR Vessel operates with bottom-drive agitators. It has a patented sparge design that supports flexible combinations of micro, medium and macro sparge sizes, helping to optimize the culture process, enhance the cell density, and maintain cell viability.

For the operation of CytoLinX^® BR, two types (air-cooled and water-cooled) of temperature control units (TCU) are available to meet customers' specific needs in different applications.

Features of CytoLinX^® BR 50-2000L Single-use Bioreactor

A single controller supports the control of multiple vessels by plugging and unplugging, which contributes to significant cost reduction.
Reliable PCS 7 system that meets ISA 88 standard, applicable for whole-plant control.
The software is designed with user-friendly interface in compliance with 21 CFR Part 11.
Flexible configurations, partly customizable upon customer requirements.
The main parts are all high-end brands and passed the inspection before leaving the factory to ensure normal operation.
The sparge provides micro, medium, and macro sparge size options to meet various processing needs.
Complete FAT, SAT, and lQOQ documents/services are available.
Rich application and operation support, and high-speed response speed.

Specifications of CytoLinX^® BR 50-2000L Single-use Bioreactor

Item	Options		CLX BR-50	CLX BR-200	CLX BR-500		CLX BR-1000	CLX BR-2000
System parameters
Working volume (L)			20– 50	40–200	100– 500		200– 1000	400–2000
Height to diameter ratio (H/D)			2.5:1 or 1.5:1	1.5:1	1.5:1		1.5:1	1.5:1
Bag lifting device and installation ladder							√	√
Accessory parameters
pH conventional electrodes	Single-use/Arc elec-		1-3	2-3	2-3		2-3	2-3
DO optical conventional electrodes	trades		1-3	2-3	2-3		2-3	2-3
PAT tools	pCO₂ /cell density		0-2	0-2	0-2		0-2	0-2
Gas mass flow controller (MFC)	Optional gas and range		4-6	4-6	4-6		4-6	4-6
Integrated pump unit	Series 1, 3, and 5		2-4	2-4	2-4		2-4	2-4
Reserved port for external pump unit	Series 5, 6, and 7		0-4	0-4	0-4		0-4	0-4
Weighing module			1	1	1		1	1
Tail gas heating jacket	Optional size		2-4	2-4	2-4		2-4	2-4
Reserved port for external weighing
Temperature control unit (TCU)	Air-cooled or wa- ter-cooled		5 kW	5 kW	5 kW		10 kW	10 kW
Control unit
Hardware	SIEMENS PCS 7 (DCS, compliant with ISA 88)
Display	19'' touch screen display, mouse and keyboard conforming to appropriate protection class, and built-in UPS
Compliance	Compliant with 21 CFR PART 11
Consumables
Sparger	Micro, medium, and large bubble size options available	Micro + large or medium + large bubble size design in the standard product
Tubing	Customizable tubing length	The tubing length in the standard in requirements				product is sufficient for post-installation weld-
Tail gas filter	Optional size	4.5''		6.7''		6.7''	10''	10''